The attraction between two adjacent non-polar molecules increases in proportion to the area of contact. Gnerally, te closeness of the tie between the two increases with greater area of van der Waal’s contact attraction and also with the degree of hydrogen bonding. Te higher the level of molecular fit, te stronger is the affinity between a molecule and the biomolecular target in therapeutic agents. Atherapeutic agent or medicine in aqueous solution is stablized by hydrogen bonding to water and dipolar solvation. I is evident that in medicines, tere trade-off; tey must be sufficiently well solvated to be soluble in water, “ut not so strongly solvated that they cannot be pulled from solution by the target biomolecule” (Corey et al 2012, p Noncyclic organic molecules are usually flexible because the barrier to rotation about single bonds having low energy.
Terefore, mst medicines’ structures have cyclic subunits with a few preferred conformations, smetimes just one. sow the conformation of prednisone, asignificant anti-inflammatory and immunosuppressive drug, aong with the preferred conformation of glucose. Wile the molecular formula for glucose is formula for prednisone is C21H26O5.
“he polycyclic framework of prednisone is quite rigid and gives the molecule a characteristic shape” (Corey et al 2012, p Concurrently, sveral polar functional groups are situated at specific sites in space, fcilitating their optimal binding to the target molecule. Tere are compounds with a divalent central atom. Acording to the theory of Valence shell electron pair repulsion (VSEPR), to electron pairs belonging to a divalent central atom will be separated to the maximum width when the bond angle is 180 degrees. Tis the will have a linear structure.
Fr example, Bryllium chloride BdCl2 with a divalent central atom is a linear molecule. Sme compounds such as carbon dioxide CO2 and allene H2C=C=CH2 are also linear, smilar to having a divalent central atom (Iwanami 2006). Fr compounds with a trivalent central atom such as boron trichloride BCl3, wen the Valence shell electron pair repulsion (VSEPR) theory is applied, te bond angle. ..
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