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Socio-economic deprivation and risk of emergency readmission and inpatient mortality in people with sickle cell disease in England

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To be considered, awoman had to meet certain criteria: she had to be healthy, wite, aed between 45 and 58, ad experienced her last menstrual bleeding 3-24 months prior to participating in the study or premenopausal symptoms such as irregular menstruations. A an exception, wmen aged between 45 and 52 were included if they had had hysterectomy and had a history of their hormone levels being stimulated by serum follicle(Schierbeck, e al. Awoman was excluded if she had: ahistory of bone disease, a uncontrolled chronic disease, pst or ongoing with glucocorticoids for over six months, sffered from cancer at any point in her life, udergone HRT within the three months leading to her participation in the study and drug or alcohol dependency.

A can be seen, te study was highly controlled. O the 2016 women enrolled into the study, 1006 were randomly picked to receive HRT(Schierbeck, e al. O these, 502 were placed under treatment while the remaining 506 received no treatment that is, tey served as the control group. Te remaining 1010 women had the choice of undergoing HRT or not.

Te article being analysed reported only the results from the randomised groups. Uon entering the survey, ech participant underwent physical examination and was screened biochemically. Ech participant was then seen six months, oe year and 2, 3 5 and ten years after being recruited into the study. A individuals participation in the study ended with the occurrence of either of two events: dath, o hospitalisation as a result of heart failure or myocardial infarction (Schierbeck, e al. Te monitoring of participants ended on June 16, and data on all participants was retrieved from the Danish civil registration database and the national register of hospital discharge.

Dta relating to the randomised participants were analysed from the onset of the study to the first day of August, 2002, amost a decade later. I order to capture the long term effects, scondary analyses were conducted for another six years until 2008 (Schierbeck, e al. Aalyses were carried out using various techniques. Dchotomous variables were tested using a χ2 test while continuous variables were tested using the t was considered statistically significant.

Dta relating to the survival of participants and their endpoints in participation was presented using the Kaplan-Meier technique and analysed using a log-rank test. Cx...

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