Incidence of squamous cell carcinoma of oral cavity or pharynx or oesophagus in such condition is seen in almost 10% of the affected cases of PVS. Disease prognosis is very good if treated in time with iron replacement therapy and mechanical dilatation of the esophagus. Patient needs to be followed up regularly in order to control development of carcinomas in such cases. Incidences of Plummer Vinson Syndrome have been dramatically reduced worldwide but still not very uncommon in developing countries where people especially females who lack inadequate nutrition and suffer from blood loss due to menstrual problems. They do not receive appropriate treatment for the same. Proper aetiology and pathology of PVS has not been understood. Only few cases have been reported in some medical journals. It is accepted that iron deficiency anemia is a principal cause and responsible for the changes in the epithelial lining of esophagus and hypopharynx. The epithelial cells of upper GI tract are vulnerable to the change in iron content of the body. However due to their “high cellular exchange mechanism”, they eventually lack in “Iron dependant enzymes”. Patients with Plummer Vinson Syndrome.
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