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Patients with Plummer Vinson Syndrome Essay Example

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Patients with Plummer Vinson Syndrome

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Patients with Plummer Vinson Syndrome. The researcher states that patients with Plummer Vinson Syndrome report difficulty in swallowing solids associated with weight loss. They also reflect anemic symptoms such as with pallor, fatigue, weakness and sometimes tachycardia. Dysphagia is often painless but progressive. Due to web formation of atrophied mucosa oesophageal lumen gets obstructed giving trouble in swallowing. Web is usually 2-3 mm wide and typically found in upper part of oesophagus. This patient can experience cheilitis, Glossitis and Koilonychia too. Sometimes on physical examination thyroid and spleen enlargement may also be found. In Annals of gastroenterology journal, it has been mentioned that Plummer Vinson Syndrome could be precancerous due to mucosal degeneration.

Incidence of squamous cell carcinoma of oral cavity or pharynx or oesophagus in such condition is seen in almost 10% of the affected cases of PVS. Disease prognosis is very good if treated in time with iron replacement therapy and mechanical dilatation of the esophagus. Patient needs to be followed up regularly in order to control development of carcinomas in such cases. Incidences of Plummer Vinson Syndrome have been dramatically reduced worldwide but still not very uncommon in developing countries where people especially females who lack inadequate nutrition and suffer from blood loss due to menstrual problems. They do not receive appropriate treatment for the same. Proper aetiology and pathology of PVS has not been understood. Only few cases have been reported in some medical journals. It is accepted that iron deficiency anemia is a principal cause and responsible for the changes in the epithelial lining of esophagus and hypopharynx. The epithelial cells of upper GI tract are vulnerable to the change in iron content of the body. However due to their “high cellular exchange mechanism”, they eventually lack in “Iron dependant enzymes”. Patients with Plummer Vinson Syndrome.

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Work cited

Chaudhary, Muhammad Aslam, Ashar Alamgir, and Amjad Obaid. "Esophagoscopy in the early detection and treatment of Plummer Vinson Syndrome." Journal of Rawalpindi Medical College. 12.2 (2008): 37-40. Web. 3 Dec.2011. <http://journalrmc.com/Journals/JRMC 2008 Vol 1-2/JRMC_Jan_2008-V-111-No-1/10-Esophagoscopy in the early detection. PDF>.

Dinler, Gonul, Burak Tander, Ayhan Gazi Kalayc, and Riza Rizalar. "Plummer-Vinson syndrome in a 15-year-old boy." Turkish Journal of Pediatrics. 51. (2009): 384-386. Web. 4 Dec. 2011. <http://www.turkishjournalpediatrics.org/pediatrics/pdf/pdf_tjp_665.pdf>.

Donohue-Cornejo, Alejandro, Dalia Abril Guzman Gastelam, Daniel Constandase-Cortez, Luis Alberto Gaitam-Cepeda, and Carlos Escalera. "Squamous cell carcinoma in the tongue and Plummer-Vinson Syndrome. A case report" Revista Odontológica Mexicana. 15.3 (2011): 189-192. Web. 3 Dec.2011. <http://www.medigraphic.com/pdfs/odon/uo-2011/uoi113i.pdf>.

Novacek, Gottfried. "Plummer-Vinson Syndrome." Orphanet Journal Of Rare Diseases. (2006): 1-36. Web. 3 Dec. 2011. <http://www.ojrd.com/content/1/1/36>.

Sawalakhe, N.R., S.U Nistala, M Sasidharan, R.T Narendran, A.D Amrapurkar, R.M Joshi, and P.M Rathi. "Synchronous Gastric Carcinoid and Gastric Adenocarcinoma with Plummer Vinson Syndrome: A Case Report and Literature Review." Annals of Gastroenterology. 22.1 (2009): 52-55. Web. 3 Dec. 2011. <http://annalsgastro.gr/index.php/annalsgastro/article/viewFile/719/531>.

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