185; Lvinson 2008, p The highly resistant nature of mycobacterium explains the easy transmission and difficult prevention of the infectious diseases. Te general features about the M. tberculosis highlight the growth rate of the pathogen, ntritional requirements, srains of the bacterium which are helpful in assessing the treatment plans and diagnostic therapies. tberculosis grows at a very slow pace and it takes 18 hours to get doubled. Tus, i comparison to other bacteria it has a slower growth rate. A mentioned earlier, M tuberculosis is an obligate aerobic, requires oxygen majorly for its growth.
Te media used for its growth is Lowenstein-Jensen medium that uses complex nutrients to support its growth. Tese include egg yolk and some dyes like malachite green. Te dyes are used to inhibit the growth of other bacteria present in the sputum samples (Levinson 2008, p Although the M. tberculosis has a very slow doubling rate, i can be grown quite favorably in the laboratory environment by providing supporting nutrients. Te important properties of M. tberculosis include the appearance and dimensions, te virulent the chemical compositions.
tberculosis appears as curved slender rods that are 2 to 4 um long and 0. 5um wide. Te bacterium possesses a particular “cord factor” that causes its virulence. Te virulent strains grow in a serpentine fashion while the avirulent strains lack this property. Te high lipid content in cell wall constituting of mycolic acids and phosphatides are the factors for causing acid-fact property and caseation necrosis, rspectively (Levinson 2008, p 161; S Georgiev 2009, p tuberculosis is transferred from one individual to another by inhalation respiratory of infected person and repeated or prolonged contact.
A it is resistant to drying, te bacteria can persist for long in the dried up sputum as well. Hmans are the natural reservoirs for the pathogen. Ater inhalation, mcobacterium enters the alveoli and multiplies in the pulmonary epithelium or the macrophages. tberculosis that survives causes two types of lesions either exudative or granulomatous. Te primary lesion is mostly in the lungs in the lower lobes of lungs. Hwever, te spread of organism can occur through erosion of the into bronchus through hematogenous spread.
Te extrapulmonary sites include the gastrointestinal tract, kdney, bain and bone. ..
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