Facebook Pixel Code
x
We use cookies to create the best experience for you. Keep on browsing if you are OK with that, or find out how to manage cookies.

Molecular Biology

This is a preview of the 4-page document
Read full text

Differential diagnosis could be replaced by reverse transcription polymerase reaction, DA sequencing and DNA microarray. Qantitative real time reverse transcription polymerase chain reaction (RT-PCR) can be used for differential expression of genes in HGDN and WD-HCC. Tis method is fast, hghly sensitive and specific. Te starting material could be liver biopsy or surgical specimen. Ientification of lymphomas by demonstration of presence or absence of clonality is done suitaby using PCR. Te most efficient markers of HCC are used to establish a specific molecular diagnostic index. The selected genes most relevant metabolic pathways involved in liver carcinogenesis and are regulated at the transcriptional level (Paradis, e al.

Qantitative real time PCR measure microMRNA which make useful biomarkers in differential diagnosis of HCC. DA microarrays is important in distinguishing different histological grades of HCC, ad genetic profiles associated with venous invasion and metastasis. Te microarray technology enables identification of specific gene expression patterns that distinguish HCC. Hp 70 and Hsp 90 families are molecular chaperones that regulate many key components of apoptotic pathways and molecular chaperones. T clarify the associated with the multistep process, te gene expression of 7 early components and 7 progressed components of nodule in nodule type HCC are analyzed.

Hp 70 in particular is a sensitive marker for the differential diagnosis of early HCC. Te expression of Hsp 70 increases in early and progressed HCC (Chuma, e al. Gnes that were classified in the immune system detoxification category were down regulated in carcinogenic cells. I the early stage of HCC development, imune surveillance deteriorates and multiple apoptosis and histocompatibility complex related genes were regulated the transition of liver cirrhosis to GI or GII HCC.

Tere are a series of genes classifiers with an accuracy of 95% distinguishing LGDN and HGDN. I addition, tese gene classifiers can effectively differentiate between GI-GII and GII-GIII HCC. I moderately to poorly differentiated HCC, te reduced rate of apoptosis could indicate major tumor progression characteristic (Maass, e al. DA sequencing is a non-invasive, erly detection and differential diagnosis of HCC. Te method has. ..

This is a preview of the 4-page document
Open full text

Related Topics

Close ✕
Tracy Smith Editor&Proofreader
Expert in: Biology, Astronomy, Systems Science
Hire an Editor
Matt Hamilton Writer
Expert in: Biology, Other, Anthropology
Hire a Writer
preview essay on Molecular Biology
  • Pages: 4 (1000 words)
  • Document Type: Essay
  • Subject: Biology
  • Level: Undergraduate
WE CAN HELP TO FIND AN ESSAYDidn't find an essay?

Please type your essay title, choose your document type, enter your email and we send you essay samples

Contact Us