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The Effects of Antidepressant Treatment in Prenatally Stressed Rats : Support the Glutamatergic Hypothesis of Stress-Related Disorders Essay Example

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The Effects of Antidepressant Treatment in Prenatally Stressed Rats : Support the Glutamatergic Hypothesis of Stress-Related Disorders

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The Effects of Antidepressant Treatment in Prenatally Stressed Rats : Support the Glutamatergic Hypothesis of Stress-Related Disorders. Rats treated with PRS reacted positively to entering the light-dark box, which shows that agomelatine and fluoxetine eradicated variations in anxiety between the controls and treated rats (Maccari et al., 2003). Findings further support the postulated hypothesis because biological dysfunctions seen in the rats, after exposing them to PRNS are similar to those exhibited by depressed patients (Morley-Fletcher et al.; 2003: Maccari et al., 2003). In stress-related ailments, empirical evidence has proven that the disorders result in changes in the hippocampus, which further, supports the postulated hypothesis (Henry et al., 994). Overall, the use of anti-depressants reverses the changes in synaptic vesicle proteins and the resulting defect in the hippocampus that produce glutamate in the PRS rats (Morley-Fletcher et al.

, 2003).
The degree of glutamate secretion had an inverse relation to anxiety, but a positive relation to memory performance in the PRS rats (Luo and Zhang, 2008). This is one of the empirical evidence from the study because the use of antidepressant treatment led to improved social memory. Therefore, it is conclusive that the article provides a validation for the glutamatergic hypothesis of stress-associated ailments (Marrocco et al., 2014). Overall, the article provides a framework for the investigation in the hippocampus of humans with such disorders. In addition, the glutamatergic transmission in the hippocampus puts forward an approach, which scholars can refer to develop therapeutic strategies (Marrocco et al., 2014).
This review has borrowed greatly from prior studies, but of which most are empirical. The aim of the study is in line with the problem, and the study employs the studies to get hold of information in connection with the postulated hypothesis (Henry et al., 994). This review presents information from actual studies, which use evidence-based approaches. This is apparent because many of the prior studies the followed an experimental approach (Luo and Zhang, 2008). The Effects of Antidepressant Treatment in Prenatally Stressed Rats : Support the Glutamatergic Hypothesis of Stress-Related Disorders.

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