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What is the current status of clinical gene therapy trials for Chronic Granulomatous Disorder

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The recent past, GCD patients were treated using prophylaxis antibiotics, antimycotics, for instance, itraconazole, or interferon gamma. In severe cases of infections, the immune system of the patients can be temporarily supported by allogeneic granulocyte infusions. These are not always effective owing to the risk of antibody development alongside antigens. Prior studies support the use of prophylactic antibiotics because they have reduced the mortality rates. In the same context, other studies have suggested that the prophylactic treatments cannot entirely change the functions of NADPH concerning protection (Lambeth, 2004). Apparently, there is negligence when it comes to utilization of common sense measures.

This is in the case of patients, who ignore instructions, which can reduce potential exposure to infectious agents. Studies recommend the use of routine immunisations against measles, varicella, and influenza to prevent sever bacterial super-infections. However, there is a recommendation to the avoidance of Bacille Calmette-Guerin (BCG) vaccination. This is because it can result to the risk of BCGitis, or BCG-osis infections. Alternatively, professional dental cleaning, flossing and the use of antibacterial when washing the mouth can help in the prevention of gingivitis.

In the same context, comprehensive dental work and surgery, in cases of bacteremia can be reduced with antibiotics such as amoxicillin (Bustamante et al. GCD manifests itself in the form of inflammation, which becomes apparent through anemia and hypergamma-globulinameia. Continued inflammation in the drainage sites and surgical wounds may result in dehiscence. Formation of granuloma can lead to occlusion of hollow viscera such as the urinary tract. When it comes to the stomach, granulomas can result in gastric outlet obstruction, which can lead to continuous vomiting. When it occurs in the urinary tract, a common manifestation is the inflammatory cystitis.

Afterwards, there is development of the granuloma in the wall of the bladder, which can obstruct the urethral (Seger, 2008). GCD patients, most of them are in lifelong antibiotics, and antifungal prophylaxis. The common antibiotic used by GCD patients is the lipophilic trimethoprim, which acts against Gram-negative bacteria, staphylocci, which are in concentration, in the host cells. The antibiotic is effective because it discourages the development of resistant pathogens. The reason for this is that it leaves the

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