In the history of nausea experienced by McCaffery, Nausea is a feeling of vomiting which gets initiated, in the brain part called the vomiting center which is a complex array of neurons coordinated by the central pattern generator. The vomiting center receives an input from the chemoreceptor trigger zone, GI tract, and the cerebral cortex. In this case study the chemoreceptor trigger zone, since chemicals such as increase of toxic substances in the blood and causes nausea to be experienced and initiates a vomit reflex. The brain detects the unusual rise of toxins in the body that constitutes a threat to life through two transmitters, such as, dopamine, which acts as D2 receptors and serotonin which acts as 5HT3 receptors (American Heart Association, 2009).
Similarly, the gastrointestinal tract (GI) gets involved in inducing a vomit because it is a source of toxin absorption (Wiviott, 2012). Chemoreceptors in the gut meditate the toxic effect of some chemotherapeutic agents like cisplatin. Nausea and vomiting get triggered through vagal nerve efferent and fibers associated with the sympathetic nervous system. Receptors get stimulated by neurotransmitters such as serotonin, histamine, and acetylcholine (Wiviott, 2012).
Acetylcholine acts as a stimulus of the intestinal tract, so myocardial infarction cause lack of enough blood supply leading to failure to carry away toxins hence the effect of nausea. More so, vestibular apparatus senses the body and then mediate the body motion sickness hence acting sensor of neurotoxins that produce disequilibrium; therefore, the myocardial infarction leads to failure by body organs such as the kidney thus making toxic levels rise causing the vestibular apparatus to detect the toxic thus inducing nausea (Subirana, 2011).
Therefore, in this case of McCaffery, the myocardial infarction causes lack of enough blood reaching the brain and failure to remove toxic substances from the body. This leads to accumulation of toxic substances in the body such as carbon dioxide then the neurotransmitters convey this message to the brain and so a feeling of nausea is initiated on McCaffery.
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